Autoimmune Cytopenias

While clinical features and survival times vary widely among patients with systemic mastocytosis (SM), little is known about patient-related factors that may impact outcomes in SM. This study of 3,403 patients with mastocytosis collected in the registry of the European Competence Network on Mastocytosis found that male sex has an important impact on SM clinical features, disease progression, and survival. The authors concluded the inferior survival observed among male patients may be due to the fact that males “more frequently develop a multimutated AdvSM [advanced SM, associated with a hematologic neoplasm] associated with a high-risk molecular background.”