Bone Marrow Failure Disorders
When Does a PNH Clone Have Clinical Significance?
This thorough review is offered as part of the Educational Program of the American Society of Hematology (ASH) 63rd annual meeting. It addresses common scenarios and clinical nuances related to assessing the significance of paroxysmal nocturnal hemoglobinuria (PNH) clones—given that only one-third of patients with PNH clones have classical PNH disease with overt hemolysis—and provides practical guidelines for the management of patients with positive PNH results. It aims to help clinicians interpret PNH flow cytometry results; understand the importance of PNH clones in performing a diagnostic assessment of patients with bone marrow failure; and recognize when it is appropriate to initiate complement inhibitor therapy in PNH. Slides and figures are available as downloadable PowerPoint slides.
Hematology ASH Education Program
