Bone Marrow Failure Disorders

Natasha L. Johnson, MSN, APRN, AOCNP^®, and Sara Tinsley, PhD, APRN, AOCN^®, both of Moffitt Cancer Center, discuss the diagnosis and management of paroxysmal nocturnal hemoglobinuria (PNH) through a case study. They describe a 22-year-old male patient who presents with abdominal pain that is progressively worsening, increased fatigue, and dyspnea on exertion. A diagnostic workup reveals hemolytic anemia and portal vein thrombosis.