Hereditary/Acquired Bleeding Disorders

Potentially Inappropriate Medications and Anticholinergic and Sedative Burden in Older Patients With Haemophilia or Von Willebrand Disease: The M'HEMORRH-AGE Study

The prospective, observational, multicenter M'HEMORRH-AGE study, conducted in France, aimed to describe the exposure of older community-dwelling patients with hemophilia or von Willebrand Disease (VWD).to potentially inappropriate medications (PIMs) and medications with anticholinergic and sedative properties. The study included 142 community-dwelling patients over 65 years of age with hemophilia (n=89) or VWD (n=53). PIMs were used by 45.8% of patients and were mainly represented by treatments related to the cardiovascular system (34.9%), nervous system (26.7%), and alimentary tract and metabolism (25.6%). In terms of anticholinergic and/or sedative medications, 37.3% of patients were exposed mainly to nervous system medications (such as analgesics). In light of the observed higher exposure to PIMs and anticholinergic/sedative medications among older community-dwelling patients with hemophilia or VWD, compared with the general population, the investigators concluded that "[i]nterventions focusing on deprescription of these inappropriate medications should be conducted in this specific population."

Journal of Clinical Pharmacy and Therapeutics