Results from a systematic review and meta-analysis of phase II and III clinical trials reporting cardiotoxicities with monotherapy or the combination of anti–PD-1/PD-L1 and/or anti–CTLA-4 agents suggests that the overall risk of cardiac immune-related adverse events (irAEs) is not significantly higher with immune checkpoint inhibitors compared with placebo or standard of care. Further, the reported severe cardiac irAEs (e.g., myocarditis and cardiac arrest) were very low.
ASCO Annual Meeting 2020 (Abstract)