KINASE INHIBITORS

In a database analysis of 137 patients treated with ibrutinib who received a pre- and post-treatment electrocardiogram (ECG), post-ibrutinib ECGs demonstrated QT interval shortening from 386 ms to 356 ms (p = .007), corrected QT interval shortening (Bazett’s formula) from 446 ms to 437 ms (p = .04), and corrected QT interval shortening (Fridericia’s formula) from 425 ms to 407 ms (p  = .003), compared with baseline ECGs.