Cardiovascular disease is the second leading cause of mortality in survivors of cancer, second only to disease recurrence. In the accompanying article, Ky provides a valuable, comprehensive overview of the cardiovascular issues of survivors of breast cancer to inform rational management. The article by Ky reviews the existing data on common cardiotoxic therapies (eg, anthracyclines and trastuzumab) and describes recent progress in cardiovascular disease detection, management, and prevention in patients with breast cancer.